Bekdaş, Mervanİnanır, Mehmetİlhan, Z.İldeş, Elif Nur2023-05-252023-05-252021Bekdas, M., Inanir, M., Ilhan, Z., & Ildes, E. (2021). Effects of serum vitamin D level on ventricular repolarization in children and adolescents. Bratislavske Lekarske Listy, 122(11), 816-820.0006-92481336-0345http://dx.doi.org/10.4149/BLL_2021_130https://hdl.handle.net/20.500.12491/10958This study was supported by the Research Fund of the Abant Izzet Baysal University, Turkey (Project no: 2019.08.01.1419) .OBJECTIVES: Low levels of vitamin D are known to increase cardiovascular mortality due to different risks. We aimed to examine whether low vitamin D levels in children and adolescents cause ventricular repolarization changes. METHODS: Sixtyseven healthy cases aged between 3.5 and 17 years were included. According to levels of vitamin D, cases were grouped as suffi cient (n=44), insuffi cient (n=13) and defi ciency (n=10). Ventricular repolarization parameters were measured manually. RESULTS: Levels of vitamin D were different for cases with insuffi ciency and defi ciency compared to suffi ciency ones (102 +/- 54.9 vs 24.4 +/- 7 ng/ml, p<0.001 and 102 +/- 54.9 vs 16.6 +/- 8.3 ng/ml, respectively, p<0.001). In the insuffi cient group the following parameters were different from suffi cient group: QTmean (357.8 +/- 25.3 vs 332 +/- 29.9 ms, p=0.012), JTc (310.8 +/- 20.2 vs 331.6 +/- 21 ms, p=0.005) and Tpe/QT (0.2 +/- 0.02 vs 0.22 +/- 0.02, p=0.02). It was found that the level of serum vitamin D correlated with JTc (r=-0.37, p=0.002), Tp-e (r=-0.29, p=0.015) and Tp-e/QT (r=-0.24, p=0.047). In the linear regression analysis, it was found that dropping level of vitamin D below normal was an independent risk factor for prolonged duration of JTc (p=0.015). CONCLUSIONS: Decline in vitamin D levels causes ventricular repolarization anomaly. As the decrease in vitamin D levels deepens, repolarization times become longer. These results could indicate that decrease in vitamin D levels can increase sensitivity to ventricular arrhythmias (Tab. 3, Ref. 45). Text in PDF www.elis.skeninfo:eu-repo/semantics/openAccessAdolescentArrhythmiChildVitamin DVentricular RepolarizationArticle10.4149/BLL_2021_13012211816820346726742-s2.0-85118615763Q3WOS:000710270800009Q4