Bucak, Yasin YücelErdurmuş, MesutTerzi, Elçin HakanKükner, AyselÇelebi, Serdal2021-06-232021-06-2320130721-832X1435-702Xhttps://doi.org/10.1007/s00417-013-2467-4https://hdl.handle.net/20.500.12491/741030th Congress of the European-Society-of-Cataract-and-Refractive-Surgeons (ESCRS) -- SEP 08-12, 2012 -- Milan, ITALYWe aimed to study the inhibitory effects of topical cyclosporine A (CsA) 0.05 % on immune-mediated corneal neovascularization, and to compare its efficacy with those of dexamethasone 0.1 % and bevacizumab 0.5 %. Immune-mediated corneal neovascularization was created in 36 right eyes of 36 rabbits. The rabbits were then randomized into four groups. Group I received CsA 0.05 %, Group II received dexamethasone 0.1 %, Group III received bevacizumab 0.5 %, and Group IV received isotonic saline twice a day for 14 days. The corneal surface covered with neovascular vessels was measured on the photographs. The rabbits were then sacrificed and the corneas excised. Paraffin-embedded sections were stained with hematoxylin-eosin and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay. The means of percent area of corneal neovascularization in Group I, II, III, and IV were 24.4 %, 5.9 %, 37.1 %, and 44.1 %, respectively. The inhibitory effect of CsA 0.05 % was found to be better than the effect found in the bevacizumab 0.5 % and control groups (p = 0.03 and p = 0.02, respectively). CsA 0.05 % was found to have significantly lesser inhibitory effects on corneal neovascularization than dexamethasone 0.1 % (p < 0.001). Apoptotic cell density was higher in Group III and Group IV than in Group I and Group II. There was no difference between Group I and Group II in terms of apoptotic cell density (p = 0.7). Topical CsA 0.05 % was shown to have an inhibitory effect on immune-mediated corneal neovascularization in rabbits.eninfo:eu-repo/semantics/closedAccessArthus ReactionCyclosporine ADexamethasoneBevacizumabCorneal NeovascularizationConference Object10.1007/s00417-013-2467-42511125552561240485782-s2.0-84887150062Q1WOS:000326052700008Q2