Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Dürüst, YaşarKarakuş, HamzaYavuz, Muhsine ZeynepGepdiremen, Ali Akçahan2021-06-232021-06-2320141300-0527https://doi.org/10.3906/kim-1309-59https://hdl.handle.net/20.500.12491/80471,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul-fonyl)- 4,5-dihydro-1 H -1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3] triazole-4,6(3 a H, 5 H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1 H, 1 3 C, 2D), mass spectra, and physical characteristics (mp and R f values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.eninfo:eu-repo/semantics/openAccessAzide1,3-dipolar Cycloaddition1,2,4-oxadiazole1,2,3-triazolePyrroleAnticancer ActivitySynthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activitiesArticle10.3906/kim-1309-593857397552-s2.0-84907206923Q3163460WOS:000340769100006Q3