Kanmaz, Zehra DilekAras, GülfidanTuncay, EsinBahadır, AyşeKocatürk, CelalettinYaşar, Zehra Aşuk2021-06-232021-06-2320161574-01531875-8592https://doi.org/10.3233/CBM-160588https://hdl.handle.net/20.500.12491/9012AIM: The aim of this study is to evaluate the diagnostic value of PET-CT scan for the prediction of EGFR mutation status and the contribution of TTF-1 expression to PET-CT scan. METHODS: We retrospectively studied 218 cases with a diagnosis of pulmonary adenocarcinoma between 2012-2014 which underwent EGFR analysis, TTF-1 and PET-CT before treatment. RESULTS: The EGFR mutation was present in 28.9% (n = 63) of cases. TTF-1 positivity was 66.9% (n = 105). Standardized uptake value (SUV max) was 16.7 +/- 6.8 in EGFR mutant type, 13.8 +/- 7.6 in cases having no EGFR mutations. According to our evaluations, high SUVmax is positively correlated with EGFR mutation status. TTF-1 expression in multivariate analysis strengthens the accuracy of detecting an EGFR mutation. CONCLUSION: PET-CT FDG uptake may, together with TTF-1 expression, help diagnosis in lung adenocarcinoma cases when evaluating for EGFR mutation status.eninfo:eu-repo/semantics/closedAccessLung CancerEGFRTTF-1Article10.3233/CBM-160588163489498270627062-s2.0-84964200296Q2WOS:000374182100022Q3