Eroğlu, MuzafferSezgin, AysunSemerciöz, AtillaMetin, AhmetKandıralı, EnginOnur, M. Ali2021-06-232021-06-2320070301-1623https://doi.org/10.1007/s11255-006-9047-zhttps://hdl.handle.net/20.500.12491/6109It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract. The aim of this study is to determine whether this up-regulation does have any effect on contractile response of rabbit bladder neck to adrenaline, acethylcholine and papaverin after long-term doxazosin treatment. Fourteen rabbits, treated with doxazosin 3 mg/kg/day p.o for 6 months, and were fed with a diet of standard laboratory rabbit chow (100 g/kg/day). Ten rabbits received the same amount of regular chow but no drug. Contractile responses of rabbit bladder neck to adrenaline acethylcholine and papaverine were measured.eninfo:eu-repo/semantics/closedAccessAcetylcholineAdrenalineBladder neckContractionPapaverineArticle10.1007/s11255-006-9047-z391137141171714132-s2.0-34248231308Q2WOS:000246203900030Q4