Şimşek, EnverKocabay, Kenan2021-06-232021-06-2320021300-01441303-6165https://app.trdizin.gov.tr/makale/TVRrM056WTIhttps://hdl.handle.net/20.500.12491/3079Mauriac syndrome is characterized by the development of dwarfism, obesity and hepatomegaly in patients with insulin dependent diabetes mellitus (1). Growth retardation and hepatomegaly in diabetes mellitus should alert physicians over the insufficient management of diabetes mellitus and the related development of Mauriac syndrome. The cause of growth failure in Mauriac syndrome has remained obscure, although it is presumably related to the poor metabolic control of diabetes (2). Growth hormone deficiency has not been found in reported cases of Mauriac syndrome (3,4). The most important growth promoting effect of growth hormone is mediated by IGF-I (5). The determination of IGF-I and insulin-like growth factor binding protein 3 (IGF-3) had become a widely used tool in the diagnostic evaluation of growth disorders. Although IGF-I levels are commonly considered an indication of growth hormone (GH) secretion or action, its synthesis and secretion are regulated by a multifactorial and complex mechanism. Nutrition, insulin, sex steroids, cortisol, and thyroxin have positive stimulatory effects on the release of IGF-I (6). We report on two cases of diabetes mellitus associated with Mauriac syndrome and limited joint mobility.eninfo:eu-repo/semantics/openAccessInsulin-Like Growth FactorMauriac Syndromeİnsülin Benzeri Büyüme FaktörüMauriac SendromuReport32542142419776