Regioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compound

Koza, GaniÖzcan, SevilŞahin, ErtanBalcı, Metin2021-06-232021-06-2320090040-4020https://doi.org/10.1016/j.tet.2009.05.090https://hdl.handle.net/20.500.12491/6444We hereby report the first preparation of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton formed by two controlled Curtius rearrangements of the corresponding acyl azides, prepared from 2-(2-methoxy-2-oxoethyl)furan-3-carboxylate via the hydrazide. Rearrangement of the acyl azides followed by trapping by nucleophiles and intramolecular trapping provided the target compounds. (C) 2009 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessPyrimidinoneFuropyrimidinoneAcyl AzideAcyl HydrazideCurtius RearrangementRegioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compoundArticle10.1016/j.tet.2009.05.090653159735976WOS:000268217000014Q1