Günpınar, ŞadiyeAlptekin, Nilgün ÖzlemDündar, Niyazi2021-06-232021-06-2320171354-523X1601-0825https://doi.org/10.1111/odi.12658https://hdl.handle.net/20.500.12491/9171OBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H. Volume of GCF was measured by Periotron 8000 (R), and enzyme-linked immunosorbent assay was used to assess MCP-1 levels. RESULTS: Compared to H controls, all clinical parameters and total amounts (pg 30 s(-1)) of MCP-1 were significantly higher in subjects with LAgP and GAgP (P < 0.05). Although concentrations of GCF MCP-1 did not differ between LAgP and GAgP (P > 0.05), total amounts of MCP-1 were higher in GAgP than LAgP (P < 0.05). CONCLUSION: It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveal that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.eninfo:eu-repo/semantics/closedAccessAggressive PeriodontitisEnzyme-Linked Immunosorbent AssayGingival Crevicular FluidMonocyte Chemoattractant Protein-1Article10.1111/odi.12658236763769282316222-s2.0-85017028373Q1WOS:000407267500012Q1