Gürbüz, OrçunKumtepe, GencehanÖzkan, HakanKaral, İlker HasanVelioğlu, YusufErcan, AbdulkadirYüksel, Ahmet2021-06-232021-06-2320200102-76381678-9741https://doi.org/10.21470/1678-9741-2018-0362https://hdl.handle.net/20.500.12491/10664Objective: To investigate the predictive value of preoperative neutrophil-lymphocyte ratio (NLR) for long-term major adverse cardiac and cerebrovascular events (MACCE), which have not yet been well described, in patients undergoing coronary artery bypass grafting (CABG). Methods: The records of 751 consecutive patients who underwent elective CABG between January 2008 and January 2010 were retrospectively enrolled and stratified according to quartiles of preoperative NLR. At 7.8-year follow-up, MACCE was considered as an endpoint. Results: Overall MACCE was 11.6% of all cases. Long-term myocardial infarction, percutaneous coronary intervention, stroke and cardiovascular mortality were found associated with the upper NLR quartile (P<0.001, P<0.001, P=0.005, P<0.001, respectively). In multivariate analysis, NLR on admission remained an independent predictor of long-term MACCE (OR 1.087, 95% CI 1.026-1.151; P=0.004), in all EuroSCORE risk groups (P<0.001; P<0.001; P=0.029). The receiver operating characteristic (ROC) curve analyses revealed an NLR cut-off value of 4.32 predicting MACCE. Conclusion: NLR is a useful and readily available predictive marker of long-term MACCE following CABG, independent of the EuroSCORE.eninfo:eu-repo/semantics/openAccessCoronary Artery BypassPercutaneous Coronary InterventionMyocardial InfarctionLymphocytesStrokeNeutrophilsArticle10.21470/1678-9741-2018-0362353274284325490982-s2.0-85086235040Q3WOS:000536043300010Q4