Çöl, CavitDinler, KahramanHasdemir, Ahmet OğuzBuğdaycı, Güler2021-06-232021-06-2320091590-8577https://hdl.handle.net/20.500.12491/4136https://www.scopus.com/inward/record.uri?eid=2-s2.0-68149162183&partnerID=40&md5=b74fdcc250706331d50447f754267be2Context: Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis. Objective: To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels. Design: Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups. Intervention: The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2nd day after pancreatic duct ligation. Main outcome measure: The levels of serum amylase were measured with an auto analyzer. Results: It was found that the mean (±SD) level of serum amylase in the control group was 947±182 IU/mL while it was 358±177 IU/mL in the experimental group (P<0.001). Conclusions: The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.eninfo:eu-repo/semantics/closedAccessAmylasesAnimal ExperimentationMelatoninPancreatitis, Acute NecrotizingArticle103306309194548242-s2.0-68149162183N/A