Günal, ÖmerDeniz, MustafaAslaner, ArifGhadouri, Salah2021-06-232021-06-2320061300-0292https://hdl.handle.net/20.500.12491/4387https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745797728&partnerID=40&md5=7cccbea2f5534f5676d341aba6b28449Objective: The aim of this study is to investigate the effect of octreotide on portal vein and peritoneal fluid TNF-? and IL-6 levels in the postoperative adhesion formation. Material and Methods: Following an "adhesion model operation", 10 rats were given octreotide subcutaneously (25 ?g/kg/day) for 10 days (study group) while other 10 rats did not receive any treatment (control group). Ten rats had only a midline laparotomy as sham. Adhesion scores, portal vein and peritoneal fluid cytokine levels were determined on the postoperative 10th day. Results: Octreotide significantly reduced the total adhesion score. It has also reduced the portal vein IL-6 and TNF-? (147 ± 2 pg/mL; 146.7 ± 2.6 pg/mL respectively) levels as compared to those of control group (193.5 ± 10 pg/mL; 195.8 ± 11.2 pg/mL respectively). There was no reduction (IL-6 132; 143 and TNF-? 132.8; 143.7) on contrary, elevations in peritoneal fluid cytokine levels, comparing to control. Conclusion: Octreotide reduces postoperative intraabdominal adhesion formation through the mechanisms those mediated by intestinal rather than peritoneal cytokine production. Copyright © 2006 by Türkiye Klinikleri.eninfo:eu-repo/semantics/closedAccessAdhesionCytokineOctreotideArticle2632522572-s2.0-33745797728Q4