Onat, AltanHergenc, GulayUyarel, HuseyinOzhan, HakanEsen, A. MetinKarabulut, AhmetAlbayrak, Sinan2024-09-252024-09-2520071420-40961423-0143https://doi.org/10.1159/000100487https://hdl.handle.net/20.500.12491/13545Aims: The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60-89.9 ml/min/1.73 m(2)) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails. Methods: After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III. Results: In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant. Conclusion: Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population. Copyright (c) 2007 S. Karger AG, Basel.eninfo:eu-repo/semantics/closedAccessdyslipidemiaglomerular filtration ratekidney dysfunctioninsulin resistancemetabolic syndromeArticle10.1159/0001004873028896173475752-s2.0-34247626158Q2WOS:000246044800003Q4