Özünal, Zeynep GüneşBayram, RecepYavuz, Muhsine ZeynepUcbek, AliAydoğar, A.Uzun, ÖzgeGepdíremen, Akçahan Akçahan2021-06-232021-06-2320130975-8585https://hdl.handle.net/20.500.12491/4855https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891096931&partnerID=40&md5=87e1b90d267162aa98f7582c34c6c54fThere are many in-vitro studies implicating that Angiotensin (Ang)II stimulates solid organ cancer growth. Effect of AngII on cell proliferation can be related to nuclear factor NFkB. The aim of the present study is to examine the effects of pyrithione, an NFkB inhibitor and AngII on breast cancer cell proliferation. MCF-7 is treated with AII (10?M) and NFkB inhibitor, pyrithione sodium (0,1-100?M). Cells are counted and photographed. WST-1 is used to measure viability in 48h after treatment and groups are fluorescent dyed with ethidium bromide. The results of cell count showed that cell proliferation was increased in AngII treated group when compared with control group. However, this increase did not show statistically significance. Cell count was decreased in pyrithione (10 and 100?M) treated group. Morphologic changes were most apparent in 100?M pyrithione group. We concluded that pyrithione alone or in combination with AngII decreased MCF-7 cell proliferation.eninfo:eu-repo/semantics/closedAccessAngIIMCF-7 Cell LineNFkBPyrithioneArticle444114162-s2.0-84891096931N/A