Düzcü, Selma ErdoğanÇetinkaya, AyhanOrallar, HayriyeDemir, Şerif2024-09-252024-09-2520222618-6454https://doi.org/10.30714/j-ebr.2022173846https://search.trdizin.gov.tr/tr/yayin/detay/523322https://hdl.handle.net/20.500.12491/15689Aim: It is known that most of the antiepileptic drugs have negative effects on the liver. Pinacidil is a\rnonselective opener of KATP channels, including the plasma membrane and mitochondria. Glibenclamide is\ran ATP -dependent K channel blocker ensuring the intake of calcium. Our aim in this experimental study was\rto examine the effects of pinacidil and glibenclamide on the liver tissue of rats with focal epilepsy.\rMethod: Sixty male Sprague Dawley rats (2-4 months old, 200-250 gr) were used in the study. The rats were\rdivided into 4 groups, 15 in each group. The groups were divided into control group, penicillin group, penicillin\r+ pinacidil group and penicillin + glibenclamide group. The craniums of the rats in the control group were\ropened and normal saline was given; Penicillin (2 ?l 500 IU) was intracortically administered to other groups\rand an experimental epilepsy model was created. At the end of the study, liver tissue of rats was taken and\revaluated in terms of vacuolar degeneration, lymphocyte infiltration, vascular congestion, sinusoidal\rdilatation, necrosis, and Kupffer cell proliferation, radial alignment of hepatic cords, central vein and portal\rvein dilatation in hepatocytes.\rResults: Venous congestion, cytoplasmic vacuolization, Kupffer cell proliferation, portal vein dilatation and\rnecrosis were distinct in the group to which pinacidil was administered, and distortion was present in the radial\rsequence (p<0.001). In addition, inflammation, venous congestion and hepatocyte necrosis were found to be\rlower in the glibenclamide given group compared to the control group (p<0.001).\rConclusion: It can be suggested that pinacidil treatment caused negative results in liver histopathological\rparameters, whereas glibenclamide was more protective by reducing inflammation, venous congestion and\rhepatocyte necrosis.eninfo:eu-repo/semantics/openAccessArticle10.30714/j-ebr.20221738465119523322