Mahdjoub, SaraDerabli, ChamseddineYildirim, MuhammetBoulcina, RaoufDebache, Abdelmadjid2024-09-252024-09-2520240022-152X1943-5193https://doi.org/10.1002/jhet.4825https://hdl.handle.net/20.500.12491/14170In this study, a highly effective microwave-assisted method employing a multicomponent domino Knoevenagel/phospha-Michael reaction has been established. This approach facilitates the synthesis of a novel set of pyrazolylphosphonate derivatives in good yields by combining aryl aldehydes with pyrazolones and trialkylphosphites, utilizing piperidine as a Bronsted base catalyst. All pyrazolylphosphonates have been characterized by means of IR, 1H-NMR, 13C-NMR, and HRMS analyses and physical methods. This protocol can be characterized by its eco-friendly nature, exceptional efficiency in terms of product yields, and short reaction times. This study describes a microwave-assisted method employing a domino Knoevenagel/phospha-Michael reaction, enabling the synthesis of pyrazolylphosphonate derivatives from aryl aldehydes, pyrazolones, and trialkylphosphites with piperidine as a catalyst. imageeninfo:eu-repo/semantics/closedAccessArticle10.1002/jhet.4825617104510562-s2.0-85192571437Q3WOS:001215893500001N/A