Tuman, Taha CanTuman, Bengü AltunayŞereflican, BetülYıldırım, Osman2021-06-232021-06-2320160271-07491533-712Xhttps://doi.org/10.1097/JCP.0000000000000503https://hdl.handle.net/20.500.12491/8804To the Editors: Quetiapine is an atypical antipsychotic indicated for the treatment of schizophrenia and bipolar disorder, both manic and depressive episodes.1 Quetiapine is also widely used off label for treatment of various psychiatric disorders.2–4 Angioedema is characterized by swelling of deep dermis and subcutaneous tissues without itching, often seen around the eyes, lips, and genitals where subcutaneous tissue is loose.5 Histamine and bradykinin release by stimulation of mast cells via foods, drugs, infections, and physical stimuli lead to vascular permeability and dilatation. Drug-related angioedema is most commonly seen with ACE inhibitors and nonsteroidal antiinflammatory drugs.6 Here, we report a male patient with angioedema associated with quetiapine.eninfo:eu-repo/semantics/closedAccessSchizophreniaBipolar DisorderQuetiapineACE InhibitorsAngioedemaLetter10.1097/JCP.0000000000000503363289290270354912-s2.0-84962097080Q2WOS:000375089900022Q2