Kaymaz, AbdulganiUlaş, FatihErimşah, SevilayÖztabag, Cansu Kara2024-09-252024-09-2520212618-6454https://doi.org/10.30714/j-ebr.2021267976https://search.trdizin.gov.tr/tr/yayin/detay/424356https://hdl.handle.net/20.500.12491/15666Aim: To investigate of the effect of intraperitoneal (IP) quercetin and bevacizumab on oxygen-inducedretinopathy (OIR) model in rats.Methods: In the study, 28 newborn rats were used. The OIR model was performed with the 50/10% oxygentechnique. The study consisted of four groups as a control group (Group I) and OIR groups (Group II, III, andIV). IP injection applied to all groups on the postnatal day (PND) 14. Groups I and II were performed 0.9%NaCl, Group III was performed IP bevacizumab, and Group IV was performed IP quercetin. All animals weresacrificed on PND 18.Results: Based on the data obtained from immunohistochemical and histopathological examinations, thenumber of vascular endothelial cell (VEC), vascular endothelial growth factor (VEGF), and tumor necrosisfactor-? (TNF-?) levels were significantly reduced in Group III and IV compared to Group II. VECs levelswere 0±0, 32.69±5.77, 2.92±0.63, and 3.64±0.36 in Group I, Group II, Group III, and Group IV, respectively(p<0.001). Likewise, VEGF values were 0.15±0.01, 7.57±1.80, 2.45±0.45, and 2.46±0.49, respectively(p<0.001). As well as TNF-? values were 0.06±0.01, 8.22±2.24, 2.32±0.32, and 2.29±0.26 in Group I, GroupII, Group III, and Group IV, respectively (p<0.001). There was no significant difference between Group IIIand Group IV in terms of VEC, VEGF and TNF-? values (range of p values was 0.96-1.00).Conclusion: The results of the present study showed that quercetin administration significantly reduced theVEC number and suppressed VEGF and TNF-?. Quercetin's anti-inflammatory and anti-angiogenesis effectwas found to be similar to bevacizumab.eninfo:eu-repo/semantics/openAccessArticle10.30714/j-ebr.202126797642131140424356