Kaymaz, AbdulganiErimşah, Sevilay2024-09-252024-09-2520212602-3695https://doi.org/10.47748/tjvr.878271https://search.trdizin.gov.tr/tr/yayin/detay/439913https://hdl.handle.net/20.500.12491/14904Objectives: To compare the effect of intraperitoneal administered Carvacrol with bevacizumab in anoxygen-induced retinopathy (OIR) model in rats.Materials and Methods: Twenty-eight newborn rats were included in the study and the OIR model wascreated with the 50/10% oxygen style. The study consisted of 4 groups and each rat in the groups receivedan intraperitoneal injection of 0.01 mL once on the postnatal 14th day. While the OIR model was not createdin Group I (control group), it was created for Groups II, III, and IV. Groups I and II were injected with 0.9%NaCl solution, Group III with bevacizumab, and Group IV with carvacrol. The rats were sacrificed on thepostnatal 18th day.Results: Histopathological and immunohistochemical studies showed that the number of retinal vascularendothelial cells (RVECs) and nuclear factor (NF)-?B levels decreased similarly in Group III and Group IVcompared to Group II. RVECs values for Group I, Group II, Group III and Group IV were measured as1.26±0.80, 27.10±3.63, 7.54±1.38, and 6.22±1.22, respectively and it differed significantly between groups(p<0.001). Likewise, NF-?B levels were recorded as 0.61 ± 0.30, 4.36±0.65, 2.68±0.44, and 2.85±0.58,respectively and it differed significantly between groups (p<0.001). On the other hand, RVECs and NF-?Blevels were similar between Group III, and Group IV (p values were 0.58 and 0.91, respectively).Conclusions: The study demonstrated that carvacrol significantly reduced retinal pathologicalneovascularizations, RVECs, and NF-?B levels. Moreover, the observed effects were comparable to those ofbevacizumab.eninfo:eu-repo/semantics/openAccessNeovascularizationcarvacroloxygen-induced retinopathyBevacizumabretinal vascular endothelial cellnuclear factor-?BArticle10.47748/tjvr.878271513540439913