Durdu, MuratBozca, Burçin CansuEnli, ServinazÖzgen, Züleyha YazıcıYaylı, SavaşPolat, Mualla2023-05-312023-05-312021Durdu, M., Bozca, B. C., Enli, S., Yazıcı Özgen, Z., Yaylı, S., Aktan, Ş., ... & Uzun, S. (2021). A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey. Australasian Journal of Dermatology, 62(4), e496-e503.0004-83801440-0960http://dx.doi.org/10.1111/ajd.13731https://hdl.handle.net/20.500.12491/11014Background:The differentiation between thepemphigoid diseases is essential for treatment andprognosis. In Turkey, data on the incidence of thesediseases are insufficient. Our aim in this study is todetermine the incidence, demographics and clinicalcharacteristics associated with diseases of the pem-phigoid group.Methods:We prospectively analysed 295 patientswith pemphigoid who visited dermatology clinics oftertiary referral hospitals in 12 different regions ofTurkey within a year. The diagnosis was based onclinical, histopathological, direct immunofluores-cence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirectimmunofluorescence and mosaic-based BIOCHIP)examinations. Clinical and demographicfindings,aetiological factors and concomitant diseasesobserved in the patients were recorded.Results:A total of 295 (female/male ratio: 1.7/1)patients with pemphigoid were diagnosed in 1-yearperiod. The overall incidence rate of pemphigoiddiseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases topemphigus group diseases was 1.6. The most com-mon pemphigoid type was bullous pemphigoid (BP,93.2%). The others were epidermolysis bullosaacquisita (3.1%), pemphigoid gestationis (2.4%), lin-ear IgA disease (1%) and mucous membrane pem-phigoid (0.3%). The most common (26.8%) possibletrigger of the bullous pemphigoid was gliptin deriva-tive drugs. The most common concomitant diseaseswith pemphigoid were cardiovascular (27.8%) andneurological diseases (23.7%).Conclusions:This study showed that the increasedfrequency of bullous pemphigoid reversed the pem-phigoid/pemphigus ratio in Turkey. Further studiesare warranted regarding the reasons for this increase.Key words: Bullous pemphigoid, acquired epider-molysis bullosa, benign mucous membrane pem-phigoid, pemphigoid gestationis, incidence study.eninfo:eu-repo/semantics/closedAccessBullous PemphigoidAcquired Epidermolysis BullosaBenign Mucous Membrane PemphigoidPemphigoid GestationisIncidence StudyArticle10.1111/ajd.13731624E496E503346429342-s2.0-85116932716Q2WOS:000706544700001Q3