Durmuş, MerveUzunlar, ÖzlemÇelik, HümeyraÇandar, Tuba2023-08-142023-08-142022Durmuş, M., Uzunlar, Ö., Çelik, H., & Çandar, T. (2022). Does alpha-1-acid glycoprotein determine for infertility in polycystic ovary syndrome?. European Journal of Obstetrics & Gynecology and Reproductive Biology, 274, 155-159.0301-21151872-7654http://dx.doi.org/10.1016/j.ejogrb.2022.05.023https://hdl.handle.net/20.500.12491/11517Objectives: The underlying cause of metabolic abnormalities and ovarian dysfunction in PCOS is thought to chronic low-grade inflammation. This study aimed to show whether alpha-1-acid glycoprotein (AGP), an inflammatory marker, predicts the risk of infertility in fertile and infertile women with PCOS. Our study had a crossectional case-control design. Study design: A total of 20 fertile and 50 infertile patients with PCOS who wanted a child were in the early follicular phase were included in our study. Among the study groups (fertil (n = 20) and infertile (n = 50), AGP, CRP, NLR, BMI, FAI, VAI, triglyceride, HDL-cholesterol, fasting blood sugar, HOMA-IR, SHBG, testosterone values and waist circumference were measured. Results: Among the inflammatory markers compared in the fertile and infertile groups included in the study, only the difference between the AGP variable was statistically significant (p = 0.011). The mean AGP was found to higher at a statistically significant level in the infertile group (p < 0.05). Age, BMI, waist circumference and AGP were weakly positive and CRP was moderately positive in the infertile group (p < 0.05). Conclusion: AGP can be a good indicator of inflammation in PCOS, especially in infertility. Revealing the risk of infertility in PCOS with AGP measurement may contribute to the correct management of the reproductive process.eninfo:eu-repo/semantics/closedAccessPolycystic Ovary SyndromeAlpha-1-Acid GlycoproteinOrosomucoidGrade Chronic InflammationAcute-Phase ProteinC-Reactive ProteinArticle10.1016/j.ejogrb.2022.05.02327415515935653904WOS:000807734200011Q3