Koçak, İdrisAkcan, YusufÜstün, CazipDemirel, CemCengiz, L.Yanık, Filiz F.2021-06-232021-06-2319990020-7292https://doi.org/10.1016/S0020-7292(99)00091-0https://hdl.handle.net/20.500.12491/5321Objective: The aim of this study was to analyze the hypothesis that there was an association between hyperemesis gravidarum (HG) and Helicobacter pylori (HP) infection. Methods: The Study group consisted of 95 pregnant women with HG and 116 asymptomatic pregnant women who were admitted to our hospital between January 1997 and October 1998. Specific serum immunoglobulin G for HP was assayed-in the sera of the study group after informed consent was obtained. Chi-square and Student's t-test were used accordingly for statistical analysis of the data. Results: Serologically positive HP infection was detected in 87 of the 95 patients with HG (91.5%) whereas 52 of the 116 asymptomatic gravidas (44.8%) serving as the control group had positive antibody concentrations against HP. The ratio of HP positivity in pregnant women with HG was significantly higher than asymptomatic pregnant women (P < 0.001). The mean index percentages of IgG titers were 73.8 +/- 9.7% in the hyperemesis gravidarum and 25.8 +/- 5.6% control group (P < 0.01). Conclusion: HP infection seemed to be significantly associated with hyperemesis gravidarum in our pregnant patient population with hyperemesis gravidarum.eninfo:eu-repo/semantics/closedAccessHelicobacter Pylori SeropositivityHyperemesis GravidarumArticle10.1016/S0020-7292(99)00091-0663251254105806722-s2.0-0344604226Q1WOS:000082839500003Q4