Erge, ErayKızıltunç, ÇağrıBalcı, Sümeyye BuseTel, Burçin Meryem AtakBilgin, SatılmışDuman, Tuba TaslamacıoğluAktaş, Gülali2024-03-082024-03-082023Erge, E., Kiziltunc, C., & Balci, S. B. A novel inflammatory marker for the diagnosis of hashimoto’s thyroiditis: platelet-count-to-lymphocyte-count ratio. Diseases 2023; 11: 15.2079-9721http://dx.doi.org/10.3390/diseases11010015https://hdl.handle.net/20.500.12491/12070Background: Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis that causes systemic inflammation in the body, leading to hypothyroidism and an enlargement of the thyroid gland. Objectives: This study aims to reveal whether there is a relationship between Hashimoto's thyroiditis and the platelet-count-to-lymphocyte-count ratio (PLR), which is used as a new inflammatory marker. Methods: In this retrospective study, we compared the PLR of the euthyroid HT group and the hypothyroid-thyrotoxic HT group to the controls. We also evaluated the values of thyroid-stimulating hormone (TSH), free T4 (fT4), C-reactive protein (CRP), aspartate transaminase (AST), alanine transaminase (ALT), white blood cell count, lymphocyte count, hemoglobin, hematocrit, and platelet count in each group. Results: The PLR of the subjects with Hashimoto's thyroiditis was found to be significantly different from the control group (p < 0.001), with the rankings as follows: hypothyroid-thyrotoxic HT 177% (72-417) > euthyroid HT 137% (69-272) > control group 103% (44-243). In addition to the increased PLR values, an increase in CRP values was also observed, revealing a strong positive correlation between the PLR and CRP in the HT patients. Conclusion: In this study, we found out that the PLR was higher in the hypothyroid-thyrotoxic HT and euthyroid HT patients than in a healthy control group.eninfo:eu-repo/semantics/openAccessHashimoto's ThyroiditisInflammationPlatelet-To-Lymphocyte RatioDiseaseThrombocytosisSuppressionArticle10.3390/diseases11010015111110368105292-s2.0-85158156243N/AWOS:000955473300001Q2