Özan, ÜlküOcak, ZeynepÖzan, FatihOktay, Elif-AybalaToptaş, OrçunŞahman, HalilYıkılgan, İhsanOruçoğlu, Hasan2021-06-232021-06-2320161698-6946https://doi.org/10.4317/medoral.21081https://hdl.handle.net/20.500.12491/8757Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis. Material and Methods: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations. Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant (p < 0.005). Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.eninfo:eu-repo/semantics/openAccessToll-Like ReceptorsPeriapical PathosisEndodonticsArticle10.4317/medoral.21081214E408E412270310662-s2.0-84985914492Q2WOS:000385028200002Q3