Kosif, RenginTürkoğlu, Şule AydınBolaç, Elif SultanDağıstan, Emine2021-06-232021-06-2320171330-0164https://hdl.handle.net/20.500.12491/3918https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069298968&partnerID=40&md5=0cfe2da44f7f5434c50f66a288c5f9edThe aim of the study was to compare the first and last magnetic resonance images (MRIs) in patients diagnosed with multiple sclerosis (MS) with MRIs of normal subjects. We wanted to investigate the region initially involved in MS patients. In this retrospective study, midsagittal plane was explored on brain MRIs taken at the time when MS diagnosis was established and the last MRI was obtained following treatment for MS. Comparison was done between healthy subjects and patients diagnosed with MS. The measures included the area of corpus callosum, cerebrum, cerebellum, pons, bulbus, fourth ventricle and pituitary gland. As a result, while there was growth in the fourth ventricle area, there was shrinkage in the other areas in MS patients. In women, the tissues involved at the beginning of the disease were pituitary gland, cerebrum and bulbus, and in men corpus callosum and cerebrum. Atrophy was not time-dependent. Assessment of the correlation between the Expanded Disability Status Scale (EDDS) and atrophy revealed an increase in EDDS (disease progression) to be associated with a decrease in the area of cerebrum and corpus callosum in men, and an increase in the fourth ventricular area in women. In conclusion, we demonstrated that pituitary gland atrophy develops in the early stage of MS, especially in women. Additional studies are needed to investigate the phenomenon of early pituitary and bulbus atrophy in women versus late atrophy of these tissues in men. © 2017, Academy of Medical Sciences of Croatica. All rights reserved.eninfo:eu-repo/semantics/closedAccessAssessmentBrainMidsagittal areasMultiple sclerosisArticle71117242-s2.0-85069298968Q4