Altuğ, CevherBüyükbayram, MuhammetKavas, ÖzgeYavuz, Muhsine Zeynep2021-06-232021-06-2320140040-4020https://doi.org/10.1016/j.tet.2014.03.106https://hdl.handle.net/20.500.12491/7879The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessGreen ChemistryAlpha-Chlorooximes5-AminoisoxazolesMITArticle10.1016/j.tet.2014.03.1067022359035942-s2.0-84899621420Q2WOS:000336868200008Q2