Karaaslan, KazımYılmaz, FahrettinGülcü, NebahatSarpkaya, AliÇolak, CemilKoçoğlu, Hasan2021-06-232021-06-2320080165-58761872-8464https://doi.org/10.1016/j.ijporl.2008.01.029https://hdl.handle.net/20.500.12491/6283Background: The aim of this study was to evaluate whether the addition of magnesium to levobupivacaine wilt decrease the postoperative analgesic requirement or not, and to investigate the possible preventive effects on laryngospasm. Methods: Seventy-five children undergoing elective tonsillectomy and/or adenoidectomy surgery. The drug was prepared as only NaCl 0.9% for the first group (Group S, n = 25), Levobupivacaine 0.25% for the second group (Group L, n = 25), and levobupivacaine 0.25% plus magnesium sulphate 2 mg/kg for the third group (Group M, n = 25). Pain was recorded at 15th minute, 1st, 4th, 8th, 16th, and 24th hour postoperatively. Pain was evaluated using a modified Children's Hospital of Eastern Ontario pain scale (mCHEOPS). Incidence of postoperative nausea and vomiting (PONV) was assessed at various time intervals (0-2, 2-6, 6-24 h) by numeric rank score. Patients were followed for laryngospasm for 1 h in recovery room after extubation. Other complications appeared within 24 h postoperatively were recorded. Results: All postoperative CHEOPS values were tower than control in both groups. Analgesic requirement was decreased significantly in both groups in comparison with control patients, but this requirement was significantly tower in Group M (p < 0.05). Although laryngospasm was not observed in Group M, the difference between groups was not statistically significant. PONV was similar in both groups. Conclusions: Levobupivacaine and Levobupivacaine plus magnesium infiltration decrease the post-tonsillectomy analgesic requirement. Insignificant preventive effect of low doses of magnesium infiltration on laryngospasm observed in this study needs to be clarified by larger series. (C) 2008 Elsevier Ireland Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessPost-tonsillectomy PainLevobupivacaineMagnesiumLaryngospasmPONVArticle10.1016/j.ijporl.2008.01.029725675681183256012-s2.0-41149166561Q2WOS:000255321200021Q3