Tuman, Taha CanTuman, Bengü AltunayŞereflican, BetülYıldırım, Osman2021-06-232021-06-2320162146-14732146-2380https://doi.org/10.5455/jmood.20160403085549https://hdl.handle.net/20.500.12491/8943https://app.trdizin.gov.tr/makale/TWpNNE1qUXpNdz09Dear Editor, In psychiatry clinic practice shows that sertraline and mirtazapine are commonly used drugs for antidepressant medication (1). Here we report a case of skin rash after using a combination of sertraline and mirtazapine. A 53-year-old man presented with a two months history of depressive mood, anhedonia, lack of energy, loss of interest, insomnia, malaise, poor concentration, loss of appetite and anxiety. We diagnosed major depression to the patient according to DSM-5 criteria, and we started sertraline 50 mg/d and mirtazapine 15mg/d as an antidepressant medication to the patient. Within three days after starting treatment, he was admitted to dermatology outpatient unit because of generalized maculopapular spreading erythematic rash over his trunk with pruritus. Laboratory investigations were within normal limits. Sertraline and mirtazapine were immediately discontinued, histamine receptor antagonist and steroid medication started. The patient’s symptoms resolved within the following five days after discontinuation of sertraline and mirtazapine. The patient had no history of drug allergy or dermatological diseases. In the past, the patient had a history of both mirtazapine and sertraline medication at different times, but there were no dermatologic side effects. The Naranjo probability scale was administered, and a score of 6 was obtained, suggesting a probable adverse effect associated with the combination of sertraline and mirtazapine (2).eninfo:eu-repo/semantics/closedAccessSertralineMirtazapineSkin RashCombination of SertralineDepressive MoodAnhedoniaLetter10.5455/jmood.20160403085549629192238243WOS:000387949200010N/A