Ögün, Muhammed NurKarabörk, ŞeydaÖnerli, MerveTürkoğlu, Şule AydınYıldız, Serpil2021-06-232021-06-2320190090-29771573-9007https://doi.org/10.1007/s11062-019-09797-6https://hdl.handle.net/20.500.12491/10094Behcet's disease (BD) is a rather rare chronic multisystemic vasculitic disease. Clear neurological involvement is observed in up to 49% of patients with BD. Cytokines play a pivotal role in the pathogenesis of BD. Data on the cerebrospinal fluid (CSF) levels of cytokines in patients with Neuro-Behcet's disease (NBD) are limited. We measured the CSF levels of Interleukin (IL)-17A, IL-17F, and IL-34 in 7 patients with NBD (median age of 38 years). Eleven control subjects were of a median age of 42 years. There was no significant difference in the male-to-female ratio and age between the NBD and control groups (P > 0.05). There was also no significant difference in biochemical values of CSF between NBD patients and control subjects. The CSF levels of IL-17 was significantly higher in patients with active NBD compared to the control (P < 0.05), whereas the CSF levels of IL-34 showed no difference compared to the control group (P > 0.05). This is the first study investigating the CSF levels of IL-34 in patients with NBD. Further studies with a larger sample size are required to confirm the role and values of the IL-34 levels in NBD.eninfo:eu-repo/semantics/closedAccessNeuro-Behcet's SyndromeCerebrospinal FluidCytokinesInterleukinsIL-17IL-34Article10.1007/s11062-019-09797-651283872-s2.0-85069965650Q4WOS:000480739800005Q4