Alper, MuratAkyürek, N.Patiroğlu, Tahir ErcanYüksel, O.Belenli, O.2021-06-232021-06-2320000036-5521https://hdl.handle.net/20.500.12491/5358DOI:10.1080/003655200750023859Heterotopic bone formation is rare in the gastrointestinal tract. We here present the clinical and pathologic details of a 56-year-old male patient with mucinous adenocarcinoma of the colon and a 70-year-old male patient with colon metastasis previously operated on for signet-ring-cell carcinoma of the stomach who was treated with radiotherapy postoperatively. Both of them showed diffuse bone metaplasia. Heterotopic bone formation is usually present with mucin-producing benign or malignant tumors. The pathogenesis of osseous metaplasia is not well known; however, it is speculated that the extravasation of mucin may have a stimulatory role.eninfo:eu-repo/semantics/closedAccessColonMucinous AdenocarcinomaOsseous MetaplasiaRadiotherapySignet-ring-cell CarcinomaArticle355556558108684622-s2.0-0034121013Q2WOS:000087406200018Q2