Büyükokuroğlu, Mehmet EminaBerashvili, DaliaGepdiremen, Ali AkçahanAltınkeser, Mustafa2021-06-232021-06-2320080970-7077https://hdl.handle.net/20.500.12491/4223https://www.scopus.com/inward/record.uri?eid=2-s2.0-53949100898&partnerID=40&md5=0dccbaf12170127ace5be1b274aea33aThis study aimed to examine possible antiinflammatory and antinociceptive effects of luteolin diglucuronide (LT), apigenin diglucuronide (AP) and semi-pure luteolin diglucuronide (S-LT) obtained from Perilla nankinensis in rats and mice. Antiinflammatory effects of LT, AP and S-LT were investigated with the carrageenaan-induced rat paw edema tests. It was found that pretreatment with LT, AP and S-LT obtained from Perilla nankinensis reduced inflammagen -induced paw edema in rats. Again, pretreatment with LT significantly diminished the nociceptive response in mice. LT and AP present in the leaves of Perilla nankinensis may partly account for the antiinflammatory and antinociceptive properties of Perilla nankinensis.eninfo:eu-repo/semantics/closedAccessAnalgesicAntiinflammatoryMousePerilla nankinensisRatArticle203190019062-s2.0-53949100898Q4