Kaya, ErtugrulYılmaz, İsmailAdmış, ÖzlemOktay, MuratBayram, Recep2021-06-232021-06-2320161556-9543https://doi.org/10.1080/15569543.2016.1178146https://hdl.handle.net/20.500.12491/3998https://www.tandfonline.com/doi/pdf/10.1080/15569543.2016.1178146?needAccess=trueThe aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d. A histopathological examination of their liver tissues was carried out 24 h after the last treatment; transaminase levels, blood urea nitrogen, urea, and creatinine were analyzed in serum. Erdosteine showed a beneficial effect by significantly improving the functional parameters particularly in alpha amanitin-induced hepatotoxicity and partially in renal toxicity. In the histopathological evaluation, the toxicity that was generated with alpha amanitin was significantly reduced by erdosteine, showing a possible hepatoprotective effect. © 2016 Informa UK Limited, trading as Taylor & Francis Group.eninfo:eu-repo/semantics/closedAccessAmanitinerdosteinehepatoprotectionhepatotoxicitysilibininArticle10.1080/15569543.2016.1178146351-2492-s2.0-84975686214Q3