Buğdaycı, GülerKaymakçı, M.2021-06-232021-06-2320080145-56801165-158Xhttps://www.cellmolbiol.org/index.php/CMB/article/view/1026/370https://hdl.handle.net/20.500.12491/6343The aim of this study was to examine the pathophysiological role of NO (nitric oxide) and MDA (malondialdehyde) in tissue in patients with nasal polyposis. We measured nitrite/nitrate (Nitrite/Nitrate; NO(2)(-)/NO(3)(-)) and MDA in tissue and plasma of NP patients (n=20) and controls (n=20). MDA level expressed as the concentration of substances reacting to thiobarbituric acid and production of NO (concentration of nitrite/nitrate in plasma) by the Griess reaction were determined. The level of NO(2)(-) and NO(3)(-) in tissue are higher than that of the normal tissue (p<0.05). The level of MDA in tissue are higher than that of the normal tissue (p<0.05). The level of NO(2)(-) and NO(3)(-) in plasma of two groups are similar (p>0.05). The level of MDA in plasma is higher than that in the normal controls (p<0.05). The change in NO(2)(-)/NO(3)(-) and MDA levels of nasal polyp patients was demonstrated. Further studies are required concerning the significance of changes in lipid peroxidation and nitrite levels in pathogenesis of nasal polyp.eninfo:eu-repo/semantics/openAccessInflammationOxidative StressMalondialdehydeNitric OxideNasal PolyposisArticle10.1170/1195410431045Q4WOS:000267199700003Q4