Çevik, Münire Özlem2021-06-232021-06-2320030735-7044https://doi.org/10.1037/0735-7044.117.4.774https://hdl.handle.net/20.500.12491/5467Meeting of the Society-for-Quantitative-Analysis-of-Behavior (SQAB 2000) -- MAY 26-27, 2000 -- WASHINGTON, D.C.Experiments I and 2 address the controversy regarding the reliability of methamphetamine effects on interval timing. A temporal discrimination procedure was used, in which the rats were reinforced for pressing the left or the right levers after short and long signals, respectively. Methamphetamine (0.5 mg/kg sc) severely disrupted operant performance at 20-100 min after injection. which disabled the measurement of drug effects on temporal perception (Experiment 1). The same dose of methamphetamine shifted the psychometric function to the left at 100-180 min after injection. indicating an increase in subjective durations (Experiment 2). Although these results confirm the role of dopamine in interval timing, that a change in the speed of a neural clock mediates the methamphetamine-induced change in temporal perception is still a working hypothesis.eninfo:eu-repo/semantics/closedAccessMethamphetaminePsychometric FunctionConference Object10.1037/0735-7044.117.4.774117477478412931962WOS:000184483600011N/A