Yıldırım, MuhammetYıldırım, ArzuGülbenek, Cansu2024-03-212024-03-212022Gülbenek, C., Yıldırım, M., & Yıldırım, A. (2022). Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological properties. Tetrahedron, 120, 132904.0040-40201464-5416http://dx.doi.org/10.1016/j.tet.2022.132904https://hdl.handle.net/20.500.12491/12106The financial supports of Bolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant no. 2018.03.03.1355) are greatly appreciated.In the current study, new polysubstituted nitropyridimines were efficiently synthesized via double Mannich cyclizations of diaryl substituted b-nitroenamines with formaldehyde and aniline derivatives under microwave irradiation for 30-40 min. Furthermore, an antioxidant study showed that some of the nitropyridimines have moderate to low scavenging activity against DPPH radical. Also, in a preliminary antibacterial activity test of selected products, only one product exhibited moderate antibacterial effect against S.Epidermidis bacteria. (c) 2022 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessMulticomponentMannichNitroenamineTetrahydropyrimidineDPPHBeta-NitroenaminesArticle10.1016/j.tet.2022.1329041201112-s2.0-85133696485Q2WOS:000877768600013Q3