Demiryürek, Bekir Enes2023-05-162023-05-162021Demiryurek, B. E. (2021). Botulinum toxin monotherapy for the treatment of essential tremor: life quality effect. Clinical Neuropharmacology, 44(1), 1-4.0362-56641537-162Xhttp://dx.doi.org/10.1097/WNF.0000000000000428https://hdl.handle.net/20.500.12491/10895Aim: This study aims to evaluate the effectiveness of botulinum toxin therapy, as a monotherapy, and its effect on quality of life in patients with essential tremor (ET) who are resistant to medical treatment or cannot tol erate optimum drug doses in the population. Method: This retrospective research was conducted between February 2019 and December 2019 with 15 adult patients (9 men and 6 women) in the 50-to-70 age group, who had a definite diagnosis of ET as evaluated by the same clinician. With the help of electroneuromyography, intramus cular onabotulinum toxin A (BoNT-A) injection was administered to the re lated muscles, not exceeding 100 U in total. Demographic characteristics and duration of disease of all patients were recorded. The tremor severity of patients before the injection, 1 month after the injection, and 3 months after the injection was assessed by the Fahn-Tolosa-Marín Tremor Rating Scale (FTM-TRS), applied by the same clinician during the face-to-face in terviews, in addition to the Questionnaire for Essential Tremor (QUEST), which was filled out by participants. Results: The first month and third month mean QUEST and FTM-TRS scores were statistically lower than that before the procedure in patients with ET after BoNT-A injection (P = 0.001, P = 0.001, P = 0.001, and P = 0.001). In addition, the mean FTM-TRS and QUEST scores for the first month after the procedure were significantly lower than the mean FTM-TRS and QUEST scores for the third month (P = 0.005 and P = 0.007). Conclusion: We believe that our study is valuable because there is no re search on the effect of BoNT-A administration on ET treatment in the our country population and because the effect of BoNT-A treatment on quality of life in patients with ET was evaluated using the ET-specific QUEST scale.eninfo:eu-repo/semantics/closedAccessEssential TremorBotulinum ToxinQuality Of LifeBotulinum toxin monotherapy for the treatment of essential tremor: Life quality effectReview Article10.1097/WNF.000000000000042844114334494732-s2.0-85100125044Q3WOS:000624037700001Q4