Bugdaycı, GülerKaplan T.Sezer S.Turhan T.Koca Y.2021-06-232021-06-2320061812-9269https://hdl.handle.net/20.500.12491/4343https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746536082&partnerID=40&md5=ba100902ae852379c5b04b366bc1af63Aim: To evaluate concentration of MMP-9 in blood plasma and broncho-alveolar lavage fluid (BALF) from patients with non-small cell lung cancer (NSCLC). Methods: Blood plasma from 40 NSCLC patients and 40 healthy donors was collected and concentrations of blood plasma and BALF MMP-9 were measured using ELISA. Correlation between MMP-9 level and gender, histological type of tumor and stage of disease was analyzed. Results: Levels of blood plasma MMP-9 were significantly higher in NSCLC patients (p < 0.0001) then in control group, and were especially high in patients with stage IV of disease (stage I vs stage IV - p < 0.005, stage II vs stage IV - p < 0.01, stage III vs stage IV - p < 0.01). Also, stage IV of NSCLC was characterized by the highest level of BALF MMP-9 (stage I vs stage IV - p < 0.002, stage II vs stage IV p < 0.002, and stage III vs stage IV p < 0.007). Correlation between blood plasma and BALF MMP-9 levels and gender or histological type of tumor was insignificant. Conclusion: Our data revealed significant correlation between tumor stage and BALF and plasma MMP-9 levels in NSCLC patients.eninfo:eu-repo/semantics/closedAccessBroncho-alveolar LavageHistological TypeMatrix Metalloproteinase-9MetastasisNonsmall Cell Lung CancerPlasmaArticle282169171168379132-s2.0-33746536082Q4