Dengiz, ÇağatayÖzcan, SevilŞahin, ErtanBalcı, Metin2021-06-232021-06-2320100039-78811437-210Xhttps://doi.org/10.1055/s-0029-1218673https://hdl.handle.net/20.500.12491/6737We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl)benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton.eninfo:eu-repo/semantics/closedAccessAcyl AzideIsocyanateCurtius RearrangementUrethanesBenzodiazepinoneArticle10.1055/s-0029-12186738136513702-s2.0-77950536239Q1WOS:000277767800016Q2