Çeker, Selçuk2023-06-052023-06-052021Ceker, S. (2021). ANTI-GENOTOXIC EFFECT OF OLEUROPEIN AGAINST AFLATOXIN B 1. Environmental Engineering & Management Journal (EEMJ), 20(11).1582-95961843-3707http://www.eemj.icpm.tuiasi.ro/pdfs/vol20/no11/Full/5_590_Ceker_20.pdfhttps://hdl.handle.net/20.500.12491/11063The author wish to thank Tuba AYDIN, assistant professor, for her help in isolating oleuropein. This study was supported by Agri Ibrahim Cecen University BAP (project no: ECZF.18.003).Aflatoxin B-1 when binds to DNA bases, cause DNA damage, thus, affects the functioning, growth, division, and control of cells. Oleuropein is a fundamental polyphenol founded in olive leaf, fruit, oil and has many benefits for human health. In this study, the possible effect of oleuropein was assessed against toxicity of aflatoxin B-1. For this purpose, the single cell gel electrophoresis and micronuclei assays were performed using the cells of human peripheral blood. As a result of this study, it was determined that oleuropein has not genotoxic effect and exhibited anti-genotoxic properties caused by aflatoxin B1 (with especially 625 mu M application) (p<0.05). On this basis, the observed anti-genotoxic effect of oleuropein against aflatoxin B-1 may occur as oleuropein has sufficient capability to reduce the lipid peroxidation and inhibit the loss of membrane integrity.eninfo:eu-repo/semantics/closedAccessAflatoxin B-1Carbonic AnhydraseComet AssayMicronuclei AssayArticle201117451750Q3WOS:000740259300005Q4