Özgür, ArmağanÜçgül, Ahmet YücelÇubuk, Mehmet ÖzgürOnat, EmrahCeylanoğlu, Kübra SerbestAydın, Bahri2023-07-212023-07-212021Ozgur, A., Ucgul, A. Y., Cubuk, M. O., Onat, E., Ceylanoglu, K. S., Aydın, B., & Yuksel, E. (2021). Descemet’s membrane area and posterior corneal power may predict the Descemet membrane folds after deep anterior lamellar keratoplasty in patients with advanced keratoconus. International Ophthalmology, 41(12), 4017-4024.0165-57011573-2630http://dx.doi.org/10.1007/s10792-021-01974-zhttps://hdl.handle.net/20.500.12491/11330Aims To investigate possible predictive topographic characteristics for the development of Descemet's membrane (DM) folds after the uneventful deep anterior lamellar keratoplasty (DALK). Methods A retrospective study included 56 eyes of 56 consecutive patients who underwent uneventful DALK using the big-bubble technique to treat advanced keratoconus. At baseline and each visit, best-corrected logMAR visual acuity (BCVA), slit-lamp findings, endothelial cell density, topographic parameters were recorded. DM area is calculated using morphogeometric modelling. Results Twelve (21.4%) of them exhibited DM folds, whereas the remaining 44 (78.6%) did not exhibit any DM folds after the surgery. The mean follow-up time was 36.3 +/- 16.7 (range, 12-71) months. The mean posterior corneal power was - 13.8 +/- 0.6 D in patients with DM folds, whereas - 13.0 +/- 0.8 D in those without DM folds (p = 0.016). The mean DM area was 53.6 +/- 2.3 (50.9-57.9) mm(2) in patients with DM folds, whereas 51.6 +/- 1.7 (47.1-53.9) mm(2) in those without DM folds (p = 0.001). The ROC curve showed that two best cut-off value for the posterior corneal power and DM area were 13.75 D and 53.8 mm(2), respectively, to predict the occurrence of DM folds. Conclusion DALK surgery seems to cause DM folds in patients with large DM area and high posterior corneal power.eninfo:eu-repo/semantics/closedAccessAdvanced KeratoconusDeep Anterior Lamellar KeratoplastyDescemet's Membrane AreaDescemet's Membrane FoldsPosterior Corneal PowerDALKArticle10.1007/s10792-021-01974-z411240174024342963502-s2.0-85110988512Q2WOS:000675789900002Q3