Similarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in children

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dc.contributor.authorYoldaş, Meyri Arzu
dc.contributor.authorTayfur, Aslı Çelebi
dc.contributor.authorHanci, Fatma
dc.contributor.authorDaniş, Ayşegül
dc.contributor.authorBolu, Semih
dc.contributor.authorAtasoy, Halil Ibrahim
dc.date.accessioned2024-09-25T20:24:04Z
dc.date.available2024-09-25T20:24:04Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: We aimed to reveal the similarities and differences between the rare and severe multisystem inflammatory syndrome (MIS-C) and active familial Mediterranean fever (FMF) disease in children. Our study may help in the early recognition of MIS-C syndrome in children and distinguish it from other diseases with similar symptoms. Methods: We evaluated the demographic and clinical characteristics, laboratory findings, treatments and outcomes of patients with MIS-C syndrome and active FMF. Results: The clinical and laboratory findings of a total of 66 patients hospitalized in our pediatric clinic with the diagnosis of active FMF (n:42) and MIS-C syndrome (n:24) were reviewed retrospectively. The reason for pediatric emergency admission was determined as resistant fever in all patients. When the clinical findings of the patients were compared, it was determined that joint and abdominal pain in the FMF group and vomiting, rash, cough, Lenfadenopati (LAP) and myalgia findings in the MIS-C group were statistically significantly higher (p<0.05). When the laboratory findings were evaluated between the two groups, the lymphocyte count and vitamin D levels were statistically significantly lower, while the leukocyte count, glucose, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), sedimentation, aspartate aminotransferase (AST), alanine aminotransferase (ALT) were found to be significantly higher in the group with MIS-C syndrome (p<0.05 ). Conclusion: We think that the results of our study may guide pediatricians and clinicians in the early differential diagnosis and management of MIS-C, by showing the similarities and differences among MIS-C patients from autoinflammatory diseases such as FMF.en_US
dc.identifier.doi10.54307/NWMJ.2023.38039
dc.identifier.endpage80en_US
dc.identifier.issn2757-7724
dc.identifier.issue2en_US
dc.identifier.startpage74en_US
dc.identifier.trdizinid1179990en_US
dc.identifier.urihttps://doi.org/10.54307/NWMJ.2023.38039
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1179990
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16292
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNorthwestern Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleSimilarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in childrenen_US
dc.typeArticleen_US

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