Measurement of local tissue water in patients with breast cancer-related lymphedema
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mary Ann Liebert, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Studies revealed that having 1.20 or upper interarm local tissue water (LTW) ratio which can be calculated through tissue dielectric constant (TDC) method might be the determinant of clinical lymphedema after breast cancer surgery. The purpose of this study was to confirm these findings and determine the sensitivity and specificity of LTW (%) measurement method in patients with breast cancer related lymphedema (BCRL). Methods and Results: Sixty-three participants were recruited to this study in two groups as follows: the lymphedema group (n=32), who had BCRL after breast cancer surgery, and the latent group (n=31), who had breast cancer surgery yet having no lymphedema. LTW (%) measurement of those was conducted with Moisture Meter-D compact (MMDc, Delfin Technologies, Kuopio, Finland) at sites 8cm proximal (biceps) and 6cm distal (forearm) from the antecubital fossa, 10cm inferior from the axilla (lateral thorax) in 2.5mm depth. Sensitivity and specificity of TDC method were analyzed based on the reference having 1.20 or upper interarm LTW ratio in both groups. Results: Absolute LTW (%) values were significantly different (p<0.001) between groups in forearm (latent: 26.963.35, lymphedema: 36.85 +/- 9.32) and in biceps (latent: 26.54 +/- 4.11, lymphedema: 36.45 +/- 9.91) while in lateral thorax reference point (latent: 35.22 +/- 7.44, lymphedema: 33.32 +/- 5.08) there was not (p=0.241). Interarm LTW ratios were significantly different (p<0.001) between groups in forearm (latent: 1.01 +/- 0.06, lymphedema: 1.40 +/- 0.35) and in biceps (latent: 1.02 +/- 0.10, lymphedema: 1.42 +/- 0.38) while in lateral thorax reference point (latent: 1.10 +/- 0.25, lymphedema: 1.07 +/- 0.16) there was not (p=0.896). Sensitivity and specificity of the TDC method were 65% and 94%, respectively. Conclusion: Absolute LTW (%) values and interarm LTW ratios were significantly different between patients with clinically diagnosed BCRL and patients with no BCRL (latent group). TDC method has been gradually gaining attention in clinical use and this method might be the preferable method in case of early detection of BCRL in patients in latent phase. Regular follow-ups would be beneficial if objective and sensitive measurement techniques were done in clinical settings.
Açıklama
Anahtar Kelimeler
Breast Cancer Related Lymphedema, Early Detection, Latent Phase, Local Tissue Water, Prevention, Tissue Dielectric Constant
Kaynak
Lymphatic Research And Biology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
16
Sayı
2
