An assessment of the effect of Ginkgo Biloba EGb 761 on ischemia reperfusion injury of intestine
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
H G E Update Medical Publishing S A
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Aims: The aim of this study was to determine the effect of Ginkgo Biloba (EGb 761) on reperfusion injury of the small bowel. Methodology: Forty-eight male 200-250g Spraque-Dawley rats in six groups were used to determine the biochemical and histopathological changes after a 30-min ischemia and 30-min reperfusion. Pre-treatment with 50mg/kg EGb 761 (Tebofortan, Karlsruhe-Germany) or 10-mL/kg saline was administered intravenously in the treatment and control groups. The superior mesenteric artery was occluded distal to the right colic artery and collateral arcades were ligated to provide complete ischemia. Ischemia was determined by the existence of pulseless or pale color of the small intestine, The return of the pulses and the reestablishment of the pink color were assumed to be the reperfusion of the intestine. Rats that were administered Egb 761 and saline were subjected to laparotomy, ischemia, or ischemia-reperfusion procedures. Mucosal lesions were graded from 0 to 5 in histopathological examination. Malondialdehyde and myeloperoxidase levels of the intestinal mucosa were measured. Results: No significant difference was noted between the control and treatment groups regarding the histopathological changes. Although malonyl-dialdehyde and myeloperoxidase levels of the reperfusion + EGb 761 group were slightly higher than the laparotomy + saline group, they were significantly lower than the reperfusion + saline group. Conclusions: We concluded that EGb 761 pre-treatment before ischemia-reperfusion decreased malondialdehyde and myeloperoxidase levels and attenuated the mucosal damage.
Açıklama
2nd International Congress on Hepatocellular Carcinoma: Eastern and Western Experiences -- DEC 09, 2000 -- TOKYO, JAPAN
Anahtar Kelimeler
Small Intestine, Reperfusion Injury, Ginkgo Biloba EGb 761
Kaynak
Hepato-Gastroenterology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
49
Sayı
43
