Clinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: A cross-sectional, multicentre study of 263 patients
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Summary
Background
Palmoplantar pustulosis (PPP) is a rare, chronic, inflammatory skin disease characterized by sterile pustules on palmar or plantar areas. Data on PPP are scarce.
Aim
To investigate the clinical characteristics and risk factors for disease severity in a large cohort of Turkish patients with PPP.
Methods
We conducted a cross‐sectional, multicentre study of patients with PPP recruited from 21 tertiary centres across Turkey.
Results
In total, 263 patients (165 women, 98 men) were evaluated. Most patients (75.6%) were former or current smokers. The mean Palmoplantar Pustulosis Area and Severity Index (PPPASI) was 8.70 ± 8.06 and the mean Dermatology Life Quality Index (DLQI) score was 6.87 ± 6.08, and these scores were significantly correlated (r = 0.52, P < 0.001). Regression analysis showed that current smoking was significantly associated with increased PPPASI (P = 0.03). Coexisting psoriasis vulgaris (PsV) was reported by 70 (26.6%) patients. Male sex prevalence, PPP onset incidence, disease duration, DLQI, and prevalence of nail involvement and psoriatic arthritis (PsA) were significantly increased among patients with PPP with PsV. Of the 263 patients, 18 (6.8%) had paradoxical PPP induced by biologic therapy, and these patients had significantly increased mean DLQI and prevalence of PsA (r = 0.03, P = 0.001).
Conclusion
Our data suggest that smoking is a risk factor for both PPP development and disease severity. Patients with PPP with PsV present distinct clinical features and patients with biologic therapy‐induced paradoxical PPP have reduced quality of life and are more likely to have PsA.
Açıklama
Anahtar Kelimeler
Psoriasis, Comorbidities, Plantaris, Palmaris
Kaynak
Clinical and Experimental Dermatology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
47
Sayı
1
Künye
S. Sarıkaya Solak and others, Clinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross‐sectional, multicentre study of 263 patients, Clinical and Experimental Dermatology, Volume 47, Issue 1, 1 January 2022, Pages 63–71,