The effects of nigella sativa seed extract on bone healing in an experimental model

dc.authorid0000-0003-3390-4623
dc.authorid0000-0001-9591-1373
dc.authorid0000-0001-9550-1999
dc.authorid0000-0002-0292-4448
dc.contributor.authorEzirganlı, Şeref
dc.contributor.authorKazancıoğlu, Hakkı Oğuz
dc.contributor.authorÖzdemir, Hakan
dc.contributor.authorİnan, Zeynep Deniz Şahin
dc.contributor.authorTek, Mustafa
dc.date.accessioned2021-06-23T19:42:58Z
dc.date.available2021-06-23T19:42:58Z
dc.date.issued2016
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractThe purpose of this study was to histologically evaluate the effects on bone healing of nigella sativa seed extract applied on calvarial defects in an ovariectomized rat model. The study included 32 female rats weighing 280 to 310g with an average age of 3 months. A defect was created with a trephine burr on each rat calvarium. The rats were divided into 2 groups (control and study) of 8 animals each. All the defects were grafted with a gelatin sponge mixed with normal saline. In the study group, nigella sativa seed extract was applied systemically using an oro-gastric tube. Half of the animals in each group were sacrificed after 2 weeks, and the others after 4 weeks. In the control groups, the defects were not completely filled with regenerated bone. Osteoblast cells were observed more in the study groups. A higher rate of osteoclasts was determined in the control groups. In addition, the nigella sativa group had a statistically greater amount of bone formation than the others group at both 2 weeks and 4 weeks (P<0.05). The systemic application of nigella sativa seed extract demonstrated incredibly positive effects on enhanced bone healing in this experimental osteoporotic model.en_US
dc.identifier.doi10.1097/SCS.0000000000002986
dc.identifier.endpage1909en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue7en_US
dc.identifier.pmid27513784en_US
dc.identifier.scopus2-s2.0-85028239426en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1905en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002986
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8657
dc.identifier.volume27en_US
dc.identifier.wosWOS:000386352100126en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTek, Mustafa
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Healingen_US
dc.subjectCalvarial Defecten_US
dc.subjectHistomorphometryen_US
dc.subjectNigella Sativaen_US
dc.subjectOsteoporosisen_US
dc.titleThe effects of nigella sativa seed extract on bone healing in an experimental modelen_US
dc.typeArticleen_US

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