Causative agents of urinary tract İnfections in elderly men with benign prostatic hyperplasia: A microbiological evaluation

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dc.authorid0000-0002-5676-6983en_US
dc.authorid0000-0002-6011-7775en_US
dc.contributor.authorBehçet, Mustafa
dc.contributor.authorAvcıoğlu, Fatma
dc.date.accessioned2023-05-09T08:30:56Z
dc.date.available2023-05-09T08:30:56Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Benign prostatic hyperplasia is an important risk factor for urinary tract infections. In this study, the causative agents of urinary tract infections were isolated from urine samples of benign prostatic hyperplasia patients aged 65 and older. Bacteremia risk and the patterns of antibiotic resistance were investigated to guide clinicians in empirical antibiotic treatment. Methods: Between 2015 and 2019, cultures of bacteria and yeast were made from urine samples from 655 patients with benign prostatic hyperplasia. The patients were divided into three groups based on age: 65 - 74, 75 - 84, and >= 85. The identification and antibiotic susceptibility tests of microorganisms were performed using the BD Phoenix (Becton Dickinson, USA) and the VITEK (R) 2 Compact (bioMerieux, France) automated systems, as well as traditional methods. Results: Microbial growth was detected in 24% of the patients. No significant differences were found concerning age (p = 0.15). The most commonly isolated microorganism was Escherichia coli (47.8%), followed by Klebsiella pneumoniae (22%), Enterococcus faecalis (8.8%), Pseudomonas aeruginosa (5.7%), and Candida albicans (4.4%). Escherichia coli showed no resistance to carbapenems. On the other hand, resistance values of 1% for amikacin, 5% for fosfomycin, 11% for nitrofurantoin, 13% for piperacillin/tazobactam, and 24% for gentamicin were detected. Resistance value for trimethoprim/sulfamethoxazole, ciprofloxacin, ceftazidime, ceftriaxone, cefixime, cefuroxime, and ampicillin were more than 50%. Also, bacterial growth occurred in 9% of blood culture samples made simultaneously with urine culture from 55 patients. Conclusions: High resistance rates to some antibiotics frequently used in empirical antibiotic treatment of urinary tract infections have reached alarming levels in elderly male patients with benign prostatic hyperplasia. Therefore, identifying resistance patterns is important to contribute to rational antibiotic use policies. In addition, the risk of Candida-related urinary tract infections and bacteremia should be considered in these patients.en_US
dc.identifier.citationBehcet, M., & Avcioglu, F. (2021). Causative Agents of Urinary Tract Infections in Elderly Men with Benign Prostatic Hyperplasia: a Microbiological Evaluation. Clinical Laboratory, 67(6).en_US
dc.identifier.doi10.7754/Clin.Lab.2020.200940
dc.identifier.endpage1446en_US
dc.identifier.issn1433-6510
dc.identifier.issue6en_US
dc.identifier.pmid34107629en_US
dc.identifier.scopus2-s2.0-85107804030en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1440en_US
dc.identifier.urihttp://dx.doi.org/10.7754/Clin.Lab.2020.200940
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000659951300016
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10849
dc.identifier.volume67en_US
dc.identifier.wosWOS:000659951300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBehçet, Mustafa
dc.institutionauthorAvcıoğlu, Fatma
dc.language.isoenen_US
dc.publisherClinical Laboratory Publicationen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElderly Menen_US
dc.subjectBenign Prostatic Hyperplasiaen_US
dc.subjectUrinary Tract Infectionsen_US
dc.subjectAntibiotic Resistanceen_US
dc.titleCausative agents of urinary tract İnfections in elderly men with benign prostatic hyperplasia: A microbiological evaluationen_US
dc.typeArticleen_US

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