Anti-proliferative effects of salmon calcitonin on SH-SY5Y neuroblastoma in vitro

Basit Öğe Kaydı
dc.contributor.authorVarol, Muhammed Ismail
dc.contributor.authorKarabörk, Şeyda
dc.contributor.authorÇetinkaya, Ayhan
dc.date.accessioned2024-09-25T20:18:29Z
dc.date.available2024-09-25T20:18:29Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: We aimed to examine the potential cytotoxic effect of salmon calcitonin, which is one of the components that regulates mineral metabolism and prevents the increase in the amount of calcium, on SH-SY5Y cells, a neuroblastoma cell line.Methods: SH-SY5Y cells were cultured in DMEM medium in the presence of 37°C and 5% CO2in conventional culture flasks. MTT assay was applied to investigate the effect of calcitonin individually on SH-SY5Y cells by treatment different concentrations for 24 h and performed. Results: In cells cultured with salmon calcitonin applied at different concentrations (0.1, 1, 3.125, 6,25, 12.5, 25, 50 and 100 nM/ml), anti-proliferation was statistically significant at concentrations of 50 and 100 nM/ml compared to the control group. It showed that 50 nM/ml and 100 nM/ml had the highest cytotoxic effect on SH-SY5Y for 24 hConclusions: Considering the proliferation curve of SH-SY5Y, the results show that salmon calcitonin treatment potentiated the proliferative activities by inhibiting cell viability in SH-SY5Y cells at concentrations of 50 and 100 nM/ml. Further studies exploring salmon calcitonin’s protective effects may prove successful and maybe it is a promising agent for cancer treatmenen_US
dc.identifier.doi10.30714/j-ebr.2022.165
dc.identifier.endpage13en_US
dc.identifier.issn2618-6454
dc.identifier.issue1en_US
dc.identifier.startpage6en_US
dc.identifier.trdizinid1161725en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2022.165
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1161725
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15688
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectSalmon calcitoninen_US
dc.subjectSH-SY5Yen_US
dc.subjectanti-proliferative effecten_US
dc.subjectneuroblastoma.en_US
dc.titleAnti-proliferative effects of salmon calcitonin on SH-SY5Y neuroblastoma in vitroen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu