Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

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dc.contributor.authorSaylan, Aslihan
dc.contributor.authorTurel, Canan Akünal
dc.contributor.authorTürel, Idris
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTorun, Ibrahim Ethem
dc.contributor.authorÇelik, Humeyra
dc.date.accessioned2024-09-25T20:18:29Z
dc.date.available2024-09-25T20:18:29Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: To investigate the effects of diazepam, which has anticonvulsant and anxiolytic effects, and diclofenac potassium, which has anti-inflammatory, analgesic and antipyretic effects, on rat kidney tissue, used in an experimental epilepsy model. Methods: 32 Wistar albino rats (2-4 months old, 200-250 gr) were used in the study. The rats were grouped in four as 8 rats in each group: Epilepsy, Epilepsy + Diazepam, Epilepsy + Diclofenac potassium, Epilepsy + Diazepam + Diclofenac potassium. Epileptic seizure model was created with penicillin (500.000 IU) injected intracortically under urethane anesthesia. 30 minutes later, diazepam (0.1 mg/kg) and diclofenac potassium (10 mg/kg) were administered intraperitoneally. At the end of the study, rat kidneys were removed and evaluated histopathologically in terms of inflammation, glomerular shrinkage, tubular dilatation, tubular epithelial thinning, desquame epithelium, brush epithelial loss, vacuolization, hemorrhage and congestion. Results: No difference was found between diazepam and diclofenac potassium in terms of vacuolization, glomerular shrinkage, tubular dilatation and hemorrhage. Inflammation, congestion and tubular epithelial thinning rate were found to be lower inEpilepsy + Diclofenac potassium and Epilepsy + Diazepam + Diclofenac potassium group when compared with Epilepsy + Diazepam group. While brush epithelial loss and desquame epithelial rate was found to be lowest in the epilepsy group, these parameters were not found to show a significant difference between drug groups. Conclusion: It was concluded that combined use of diazepam and diclofenac potassium in their effects on kidney are more useful than their single use.en_US
dc.identifier.doi10.30714/j-ebr.2023.171
dc.identifier.endpage87en_US
dc.identifier.issn2618-6454
dc.identifier.issue2en_US
dc.identifier.startpage77en_US
dc.identifier.trdizinid1175423en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2023.171
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1175423
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15699
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleHistopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy modelen_US
dc.typeArticleen_US

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