The Effect of Wet Cupping Therapy on Anxiety and Thiol/Disulfide Homeostasis in Premature Ovarian Failure: An Experimental Study

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dc.contributor.authorÇelik, Humeyra
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorAlişik, Murat
dc.contributor.authorYis, Özgür Mehmet
dc.date.accessioned2024-09-25T20:19:47Z
dc.date.available2024-09-25T20:19:47Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: The effect of wet cupping therapy on anxiety\rand thiol/disulfide homeostasis was evaluated in rats with premature\rovarian failure (POF) induced by cyclophosphamide (CYC). Material\rand Methods: Twenty four Wistar Albino female rats were divided\rinto control (n=6), POF (n=6), wet cupping (n=6), POF+wet cupping\r(n=6) groups. CYC at a dose of 200 mg/kg was injected intraperitoneally\rto POF and POF+wet cupping groups. One week later, wet cupping\rtherapy was applied to wet cupping and POF+wet cupping groups for\r5 minutes. The next day, Open Field Test and Elevated Plus Maze Test\rwere applied to all experimental groups to evaluate anxiety. After sacrification,\rto assess pattern formation, endometrial thickness and ovarian\rreserve were measured with hematoxylin-eosin staining.\rThiol/disulfide homeostasis and erythrocyte oxidized-reduced glutathione\rlevels were measured in serum to measure oxidative stress. Results:\rAlthough there was no statistical significance, it was observed\rthat anxiety decreased in POF+wet cupping compared to POF group.\rThere was no change in thiol-disulfide values in POF+wet cupping\rcompared to POF group (p>0.05). Conclusion: Wet cupping therapy\rdid not reduce anxiety in the experimental POF model and did not shift\rthe balance to positive in thiol/disulfide homeostasis in favor of thiols.\rHowever, the obtained graphics, numerical data and high standard deviation\rsuggest that meaningful data could be obtained with more subjects.en_US
dc.identifier.doi10.5336/jtracom.2021-83703
dc.identifier.endpage21en_US
dc.identifier.issn2630-6425
dc.identifier.issue1en_US
dc.identifier.startpage12en_US
dc.identifier.trdizinid533586en_US
dc.identifier.urihttps://doi.org/10.5336/jtracom.2021-83703
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/533586
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15771
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGeleneksel ve Tamamlayıcı Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleThe Effect of Wet Cupping Therapy on Anxiety and Thiol/Disulfide Homeostasis in Premature Ovarian Failure: An Experimental Studyen_US
dc.typeArticleen_US

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