The Effect Of Ranolazine Treatment Administered Before Coronary Artery Bypass Surgery On Perioperative Myocardial Damage In Patients With Stable Angina Pectoris

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dc.contributor.authorYilmaz, Mehmet Fatih
dc.contributor.authorEfe, Süleyman Çağan
dc.contributor.authorAcar, Emrah
dc.contributor.authorGeçtin, Çetin
dc.contributor.authorInanir, Mehmet
dc.contributor.authorKarabay, Can Yücel
dc.contributor.authorIzgi, Ibrahim Akın
dc.date.accessioned2024-09-25T20:23:46Z
dc.date.available2024-09-25T20:23:46Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective:Ranolazineisapiperazinederivativethathasbeenapprovedasanantianginal agent.Itisprimarilyusedasasecondlineantianginalagentinstablecoronaryarterydisease.Thestudywasdesignedconsideringthattheactiveingredientranalozine,\rwhich has antiischemic effectsthrough ischemic sodiumchannels, can reduce ischemia in the perioperative period and reduce\rthe frequency of perioperative myocardialinfarction.\rMethods: The study included patients with stable angina pectoris who underwent coronary angiography between January\r1, 2015 and June 30, 2016 at Koşuyolu Training and Research Hospital and who were diagnosed with multi-vessel disease\ror LMCA disease, and then for whom the joint council of Cardiology-Cardiovascular Surgery made a decision in favor of\rcoronary artery bypass grafting.\rResults: The mean age was 61.2 ± 8.6 years in the ranolazine group, while the mean age of the patients receiving standard\rtherapy was 57.9 ± 8.8 years (p = 0.073).The EuroSCOREs of the patients before the operation which were used to predict\rintraoperative mortality were similar. Mean troponin value of Group 1 patients at 0 hour was 1.70 (1.13-2.77), while mean\rtroponin value of the patients in Group 2 at 0 hour was 2.76(1.69-6.20)(p=0,01).\rConclusion:In the presentstudy,the immediate postoperative troponin 0 valuewasfound to be lowerin the ranolazine group.\rThere was no statistical difference in terms of troponin valuesmeasured at 12 and 24 hours.In thisstudy,we showed that early\rmyocardial damage was significantly reduced with ranolazine treatment.en_US
dc.identifier.doi10.5505/ktd.2022.20438
dc.identifier.endpage225en_US
dc.identifier.issn2147-0758
dc.identifier.issue1en_US
dc.identifier.startpage219en_US
dc.identifier.trdizinid522408en_US
dc.identifier.urihttps://doi.org/10.5505/ktd.2022.20438
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/522408
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16107
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofKocaeli Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleThe Effect Of Ranolazine Treatment Administered Before Coronary Artery Bypass Surgery On Perioperative Myocardial Damage In Patients With Stable Angina Pectorisen_US
dc.typeArticleen_US

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