Antimicrobial activity of tetra substituted benzene derivatives
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
2,4,6-triklor tribrom and triiyot anilinlerden sentezlenmiş olan [1-klor (veya brom veya iyot)-2,4,6-triklor vel-klor (veya brom veya iyot)-2, 4,6-tribrom ve 1-klor (veya brom veya iyot)-2,4, 6-triiyot benzen] gibi tetra substitue benzen türevlerinin in vitro antibakteriyel ve antifungal özellikleri incelenmiştir. Tetrasubstitute benzene türevleri sentezlenmiş, IR ve NMR gibi spektroskopik yöntemlerle yapıları aydınlatılmıştır. Antibakteriyel ve antifungal aktiviteler; Minumum inhibisyon konsantrasyonu (MIC) metodu ile gram-pozitif bakteriler ( Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633) ve gram-negatif bakteriler (Yersinia enterocolitica ATCC 1501 Escherichia coli ATCC 11230) ve kendi koleksiyonumuzdan olan maya {Candida albicans) bakterilerine karşı ölçülmüştür. Bu bileşiklerde halojen sübstitüentin büyüklüğü arttıkça antimikrobiyal aktivite azalmaktadır.
The in vitro antibacterial and antifungal activities of tetrasubstituted benzene derivatives [1-chloro (or bromo or iodo)-2,4,6-trichloro and 1-chloro (or bromo or iodo)-2, 4,6-tribromo and 1-chloro (or bromo or iodo)-2, 4, 6-triiodo benzenes] derived from 2,4,6-trichloro tribromo and triiodo anilines were investigated. Tetrasubstituted benzene dervatives synthesized and identified by spectroscopic means 1R and NMR. The antibacterial and antifungal activities were measured by Minumum inhibition concentration (MIC) method against gram-positive bacteria i.e. Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633; Gram-negative ones as Yersinia enterocolitica ATCC 1501 Escherichia coli ATCC 11230 and fungus as Candida albicans from our strain collection. Antimicrobial activies of these compounds tended to decrease with increasing size of halogene substitutents.
The in vitro antibacterial and antifungal activities of tetrasubstituted benzene derivatives [1-chloro (or bromo or iodo)-2,4,6-trichloro and 1-chloro (or bromo or iodo)-2, 4,6-tribromo and 1-chloro (or bromo or iodo)-2, 4, 6-triiodo benzenes] derived from 2,4,6-trichloro tribromo and triiodo anilines were investigated. Tetrasubstituted benzene dervatives synthesized and identified by spectroscopic means 1R and NMR. The antibacterial and antifungal activities were measured by Minumum inhibition concentration (MIC) method against gram-positive bacteria i.e. Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633; Gram-negative ones as Yersinia enterocolitica ATCC 1501 Escherichia coli ATCC 11230 and fungus as Candida albicans from our strain collection. Antimicrobial activies of these compounds tended to decrease with increasing size of halogene substitutents.
Açıklama
Anahtar Kelimeler
Mühendislik, Kimya
Kaynak
Communications Series:B Chemistry and Chemical Engineering
WoS Q Değeri
Scopus Q Değeri
Cilt
51
Sayı
2
